The No Observed Adverse Effect Level (NOAEL)  is a toxicological parameter representing the highest exposure level at which there are no statistically or biologically significant increases in the frequency or severity of adverse effects between the exposed population and its appropriate control.
The Scientific Committee on Consumer Safety (SCCS) now considers NOAEL as the standard requirement in the safety assessment of substances used in cosmetic products. A NOAEL value is indeed essential in order to calculate the Margin of Safety (MOS), that is the ratio bewteen NOAEL and the Systemic Exposure Dose (SED). A MOS under a score of 100 means the substance not safe for being used in cosmetic products.
To address the strong necessity of a database storing solid NOAEL values, we created this website where users that have joined the project can check and download NOAELs found in international peer reviewed journals or databases.
In our toxicological datasheeet we provide all the available information needed for MOS calculation and, if possible, for SED calculation.


From the main menu you can access the search form for the NOAEL of the substances stored in the database. There are two search boxes, one for the INCI name (with autocomplete function) and another one that you can fill with the CAS number or synonyms.
Toxicological informations are only shown for registered users. Anonymous users can only see INCI name and CAS number.


For technical info about the NOAEL project visit the FAQ section, if you have more questions, contact Dr. Roberto Narducci: or

For info about the cost of subscription click this link, if you have more questions contact Federica Cambiganu: 
PIN s.c.r.l. - Piazza Giovanni Ciardi 25, 59100 - Prato


Substances in database
Example sheet
Database access
Last subscription


We inform you that all the toxicological datasheets in the database have been updated. The broken links have been fixed and the material (where needed) uploaded. Please download the toxicological sheets in case of modifications.

Read more

29/10/2020 - 17:03

Category: Website changes

Due to some problems at our servers, you should send email to the following address (not to


Read more

17/07/2020 - 16:02

Category: Attività del sito

Since all the former subscriptions allowed us to store sufficient money to pay website costs for the next year to come, we decided to temporarily halve the cost for joining the project.
As a consequence, all the active subscriptions will be extended to 10 months for free.

Read more

08/11/2015 - 10:50

Category: Announce

Visits - current year -

Website visits

Last Tweets

06/06/2016 - 11:11
Nuovo componente inserito: Simmondsia Chinensis (Jojoba) Seed Oil
29/05/2016 - 10:04
Nuovo componente inserito: Linum Usitatissimum seed oil Error
27/05/2016 - 16:38
Nuovo componente inserito: Soybean oil


Project coordinator

Toxicological datasheet creation

Content revision

Website Administration

Subscriptions & Contacts

To get more info about the NOAEL project, go to FAQ section or contact Roberto Narducci at this address: or
For info about subscription costs click the following link or contact Federica Cambiganu:
PIN s.c.r.l. - Piazza Giovanni Ciardi 25, 59100 - Prato