ItalyThe NOAEC is a parameter identical to the NOAEL except for the fact that a concentration is used instead of a dose (the most common case is when a gaseous substance is administered to the animal).
Most frequently, NOAECs are expressed as mg/m3, mg/L or ppm. Two parameters are needed in order to provide a conversion for the unit of measure:
- The mean respiratory volume of the animal used for the test
- The value of absorption of the inhaled substance
The latter parameter is fundamental, as the assumption of an absorption equal to 100% would lead to a big underestimation of the real toxicity (in case for example all the symptoms are caused by the 10% of the administered substance).
The NOAEL-project is capable of converting the NOAEC to NOAEL only if the dermal absorption is available; otherwise the substance will be classified as "No NOAEL found".
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